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Life Extension Track Record

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An Impeccable Track Record of 34 Years of Scientific Achievements in Health and Longevity

2007-2009: Vitamin D, Hormones, Prostate Cancer

  • In 2007, Life Extension revealed how ubiquinol CoQ10 reversed congestive heart failure in cases where conventional CoQ10 was shown to be ineffective.

  • In 2007, Life Extension ascertained what dose of green tea was required to protect against certain cancers and vascular diseases, and why drinking only a few cups of green tea a day is not enough.

  • In 2007, Life Extension showed how cancer cells lurk in the prostate glands of many aging men, and how to inhibit an enzyme (5-lipoxygenase) that enables these isolated malignant cells to develop into full-blown prostate cancer.

  • In 2007, Life Extension showed that those drinking bottled water were at significant risk of a lethal magnesium deficiency.

  • In 2007, Life Extension revealed one overlooked reason why humans contract the flu much more frequently in winter months and what could be done to guard against this.

  • In 2007, Life Extension revealed published findings about how people with higher blood levels of vitamin E slashed their risk of dying over a 19-year period and showed that it was not possible to attain adequate vitamin E levels through diet alone.

  • In 2007, Life Extension unveiled a comprehensive program to sharply reduce the high cost of prescription drugs while also protecting consumers against dangerous side effects.

  • In 2007, Life Extension showed for the first time how Coumadin® (warfarin) drug users could safely benefit from low-dose vitamin K. Most doctors still tell their Coumadin® patients to avoid even foods that contain vitamin K, whereas Life Extension showed that most Coumadin® users can benefit from consistent low-dose vitamin K, which can help stabilize coagulation markers in the blood while protecting against arterial calcification and bone density loss — two common side effects associated with this drug.

  • In 2007, Life Extension showed that low blood levels of the omega-3 fatty acids EPA and DHA are independent risk factors for heart attack and angina.

  • In 2007, Life Extension exposed how pharmaceutical special interests were seeking to ban over-the-counter sales of DHEA so they could sell this safe, anti-aging hormone as a prescription drug. Life Extension members inundated Congress with protests and prevented DHEA from being removed from the supplement marketplace.

  • In 2007, Life Extension uncovered five anti-cancer drugs that the FDA was not approving, despite human clinical studies documenting both safety and efficacy. Life Extension organized patient advocate groups to contact their members of Congress to protest the unjust denial of these medications to terminally ill cancer patients. One of these drugs (Provenge®) was finally approved by the FDA in 2010.

  • In 2007, Life Extension alerted its members about the potential danger of inhaled insulin drug therapy. The company making this drug soon took it off the market.

  • In 2007, Life Extension compiled data showing that supplementing with higher-dose vitamin D could significantly reduce the risk of the most common age-related disorders, including cancer, chronic inflammation and heart disease. The Foundation wrote the President of the United States urging that a national emergency be declared to urge every adult to consume at least 1000 IU a day of vitamin D. The Foundation also offered to donate 50,000 one-year-supply bottles of vitamin D to the federal government to give to those who could not afford this low-cost supplement.

  • In 2007, Life Extension showed how mainstream oncologists are failing to optimally prescribe FDA-approved therapies and offered a practical solution for cancer patients to consider.

  • In 2007, Life Extension reported on an enhanced form of ubiquinol CoQ10 that was shown to absorb into the blood even better than the ubiquinol Life Extension had introduced to the world just one year prior.

  • In 2007, Life Extension unveiled its multi-pronged scientific research program to more efficiently develop new cancer drugs.

  • In 2008, Life Extension revealed how the consumption of specific plant lignans can slash prostate cancer risk.

  • In 2008, Life Extension published the "Seven Pillars to Successful Weight Loss" that identified why virtually all fat-loss programs fail and provided a comprehensive scientific rationale to induce weight loss in aging humans.

  •  In 2008, Life Extension published confirmatory data that radiation from medical x-rays and especially highly radioactive CAT scans increase risk of cancer.

  • In 2008, Life Extension published data showing why more Americans are depressed, overweight and suffer sleep disturbances than ever before. The Foundation then revealed a novel method to enable tryptophan supplements to safely increase brain serotonin to improve mood, decrease carbohydrate craving and facilitate restful sleep.

  • In 2008, Life Extension found itself in the unusual position of defending the proper use of statin drugs in high-risk patient groups when the media misinterpreted some scientific reports. Most Foundation members, however, find they can achieve optimal cholesterol, LDL and HDL using safer natural approaches, rather than drugs.

  • In 2008, Life Extension issued a meticulous rebuttal to the FDA’s attack against bio-identical hormones and provided a scientific rationale for using natural testosterone and estrogen to reverse certain manifestations of aging.

  • In 2008, Life Extension published a report titled “The FDA Indicts Itself,” where for the first time the FDA itself admitted it was scientifically incapable and incompetent to keep up with medical discoveries.

  • In 2008, Life Extension uncovered an orally ingested supplement that protects the skin from solar radiation.

  • In 2008, Life Extension announced a startling breakthrough whereby the clinical course of Alzheimer’s disease was reversed. The Foundation then announced it was funding an expanded research program to validate the remarkable cognitive improvements observed in Alzheimer’s patients receiving this novel drug therapy.

  • In 2008, Life Extension uncovered topical agents being used in Europe to reverse the outward appearance of cellulite.

  • In 2008, Life Extension launched a political campaign to radically overhaul the FDA. The Foundation’s position paper revealed how the FDA is the major impediment to life-saving advances in medicine.

  • In 2009, Life Extension analyzed 13,892 blood tests measuring 25-hydroxyvitamin D levels in a group of dedicated supplement users and discovered that 85.7% had insufficient vitamin D status. This unprecedented analysis of achieved vitamin D serum levels in a large group of high-dose supplement users reveals that most aging people require a dose of 5,000 IU or higher of this critical disease-preventing nutrient.

  • In 2009, Life Extension uncovered a glaring omission by most in the conventional medical establishment and verified Life Extension’s previous recommendations that those developing any symptom of influenza, swine flu or even the common cold should implement immediate treatment with specific nutrients, hormones, and antiviral drugs with the objective of eradicating the infectious agent within 24 hours of the first symptom appearing.

  • In 2009, Life Extension introduced an oral form of cyanocobalamin vitamin B12 that absorbs up to 10 times better.

  • In 2009, Life Extension cut through the heated debate on statin drugs and revealed why the Vytorin® trial failed to live up to conventional medicine’s expectations. In this rare instance, Life Extension found itself defending the interest of a pharmaceutical company that appeared to be too overwhelmed by negative media coverage to put this study in proper scientific context.

  • In 2009, Life Extension reiterated its long-standing position that inadequate vitamin D intake was directly responsible for millions of needless deaths.

  • In 2009, Life Extension introduced Americans to a non-invasive diagnostic procedure available in Europe to detect the presence of small, and otherwise undetectable, lymph node lesions in patients with cancer.

  • In 2009, Life Extension revealed how the FDA is in worse shape than anyone ever imagined and spearheaded a new public relations drive to raise the public’s awareness of the state-sponsored “carnage” of the American citizenry.

  • In 2009, Life Extension documented how the public suffers widespread deficiencies of nutrients (like selenium, vitamins C, D, and E) while the mainstream media alleged that these same nutrients provide no health benefits. Life Extension then meticulously exposed how horrifically flawed studies were used to support the media’s baseless assertions.

  • In 2009, obese Americans were shown for the first time to outnumber those who are merely overweight. Life Extension published overlooked research findings indicating substantial fat-loss effects in response to the proper use of bioidentical hormones, certain prescription drugs, and nutrients, along with lifestyle changes. The reason these proven weight-loss strategies have still not caught on, the Foundation asserted, is that when used in isolation, they often fail to meet the expectations of corpulent individuals. In an eye-opening report, Life Extension revealed how to interpret blood test results to utilize an armada of medications, natural hormones, and lifestyle alterations that can safely induce substantial and sustainable weight loss.

  • In 2009, a proven anti-glycating nutrient especially beneficial for diabetic-related kidney disease (pyridoxamine) was banned by the FDA. In this instance, the FDA bowed to pharmaceutical financial interests by reclassifying this natural B-vitamin as a drug. Life Extension uncovered how the FDA’s politically biased decision may condemn millions to needless suffering and organized a protest to The White House seeking to reverse the FDA’s heinous capitulation to a pharmaceutical company.

  • In 2009 in a shocking exposé, Life Extension uncovered how a corrupt regulatory system causes generic drug prices to be far higher than they should be. A free market solution was then proposed that would save consumers up to 94% on generic drugs, slashing prices in some cases to only pennies a day!

  • In 2009, Life Extension unveiled new blood test ranges to optimally reduce one’s risk of suffering a heart attack and stroke. Contrary to conventional medicine, these new science-based blood test ranges enable aging humans to slash their odds of contracting vascular disease.

  • In 2009, absurd lies promulgated by Big Pharma and enforced with FDA police-state powers were causing females to be prescribed dangerous hormone drugs instead of bioidentical hormones long recommended by Life Extension. To educate the media, physicians, and academia, Life Extension published a meticulously documented White Paper that assembled a plethora of research indicating that women may safely benefit from individual doses of natural estrogens and progesterone combined with healthy lifestyles.

  • In 2009, Life Extension analyzed results from 13,892 blood tests in members who had their levels of vitamin D (25-hydroxyvitamin D) evaluated over an 18-month period. The results revealed a startling 85% of these supplement users had insufficient levels (under 50 ng/mL) of 25-hydroxyvitamin D. This revelation enabled Life Extension® members to increase their intake of this low-cost vitamin to 5,000–10,000 IU each day to achieve optimal levels of this health-protecting nutrient.

2010 and the Future ...

  • In 2010, a landmark study of caloric restriction in primates demonstrating a three-fold reduction in mortality, confirming what Life Extension published 30 years prior. This led to development of a formulation that provides five natural compounds shown to mimic effects of caloric restriction on gene expression without severe dietary modification.

  • In 2010, to counter the abnormally high blood sugar and dangerous pre-diabetic state suffered by an estimated 60 million Americans, Life Extension uncovered a novel group of enzyme-inhibitors shown to control glucose levels, improve blood markers of health, and regain glycemic balance.

  • In 2010, Life Extension added shilajit to its ubiquinol CoQ10 formulation to better enhance mitochondrial energy output.

  • In 2010, Life Extension stressed the benefits of pomegranate, resveratrol, and quercetin in enhancing a little-recognized blood enzyme called PON-1 (paraoxonase-1). Optimized levels of PON-1 have demonstrated the ability to block lipid peroxidation and may serve as a potent defense against heart disease, metabolic syndrome, arthritis, and certain cancers.

  • In 2010, Life Extension reported that curcuminoids and andrographolides, a set of safe, multi-targeted natural agents, have been identified to disrupt the inflammatory cascade involved in rheumatoid arthritis and reduce joint swelling, pain, and stiffness.

  • In 2010, Life Extension was once again vindicated in its 30-year crusade to expose financial and scientific fraud as pharmaceutical giant Pfizer was forced to pay the largest criminal fine ever imposed in the United States ($1.195 billion). This fine was a result of government claims that Pfizer illegally promoted the sale of its arthritis drug Bextra® for uses and doses the FDA specifically declined to approve due to safety concerns. (Bextra is a COX-2 inhibitor, a drug class that Life Extension warned its members against taking in year 2000.)

  • In 2010, Life Extension reported that Hibiscus sabdariffa, similar to the cranberry, prevents bacteria that cause urinary tract infections from adhering to the lining of the urinary tract and bladder. Compared to the cranberry in vitro, hibiscus demonstrated a stronger antimicrobial effect — especially against Candida albicans, the fungus responsible for yeast infections.

  • In 2010, Life Extension announced a revolutionary new test, currently available in Europe that measures the characteristics of circulating tumor cells (CTCs) and allows for specific conventional and natural treatments to be tailored to cancer patients.

  • In 2010, Life Extension reminded male Life Extension members about the critical need to maintain estrogen blood levels between 20–30 pg/mL. This longstanding recommendation was confirmed the year before when the Journal of the American Medical Association published a study that showed men with unbalanced estrogen levels were up to 317% more likely to die from heart failure.

  • In 2010, to combat chronic kidney disease suffered by 26 million Americans, Life Extension recommended clinically supported interventions such as CoQ10, silymarin, resveratrol, and lipoic acid in addition to nutrients like pyridoxal 5’-phosphate, folate, omega-3 fatty acids, and vitamins C and E.

  • In 2010, a groundbreaking scientific study, partially funded by the Life Extension Foundation and published in the journal Regenerative Medicine, demonstrated that the aging of human cells can be reversed in vitro.

  • In 2010, Life Extension published original research using its own member’s blood test results that revealed a startling 86% of men had less than optimal testosterone levels. Aside from waning sexual performance, depression, and diminished strength, low testosterone has been definitively linked to men’s risk of death from all causes.

  • In 2010, Life Extension reported on a strawberry extract called fisetin that has been shown to enhance the calorie restriction mimetic action of resveratrol.

  • In 2010, the Life Extension Foundation stepped up its funding of a human clinical trial of an immune augmentation therapy that has been shown to cure cancer in mice.

  • In 2010, the federal government admitted that radiation from CT scans contributes to 29,000 cases of cancer in one year and 15,000 needless deaths. Since its inception, Life Extension warned its members to avoid any kind of medical X-ray unless absolutely necessary because of increased cancer risks.

  • In 2010, Life Extension reported that omega-3 fatty acids have been associated with increased volume of the brain’s gray matter. Normal aging results in a loss of brain mass.

  • In 2010, following the remarkable discovery that blood vessel cells can transform into bone-forming cells — confirming a link between atherosclerosis and osteoporosis — Life Extension maintained its advocacy of regularly supplementing with vitamin K, which optimizes bone mineralization and prevents calcium deposits in vascular tissue.

  • In 2010, Life Extension unveiled a multi-modal weight loss program that for the first time combines the use of natural hormones, certain drugs, and novel nutrients that attack the underlying causes of age-related weight gain.

  • In 2010, the FDA finally approved Provenge® to treat prostate cancer. Life Extension had battled the FDA to have Provenge® approved for nearly a decade. The FDA’s delay of this immune-boosting therapy is calculated to have caused 82,000 lost life years.

  • In 2010, Life Extension, which has urged supplementation with vitamin K since the late 1990s, reported compelling clinical evidence showing that vitamin K can prevent, and in some cases treat, a variety of common and dangerous cancers.

  • In 2010, Life Extension introduced a novel compound called PQQ (Pyrroloquinoline quinone), that has been shown to rejuvenate aging cells by promoting the growth of new mitochondria.

  • In 2010, Life Extension reported that the berry extract C3G (cyanidin-3-glucoside) has demonstrated the ability to enhance visual acuity in low-light conditions.

  • In 2010, Life Extension introduced a patented, clinically supported wheat oil ingredient shown to rehydrate dry aged skin from within.

  • In 2010, Life Extension reported on a safer, better, and clinically proven form of chromium that has been shown to improve glucose control and insulin sensitivity in a study of diabetics taking one of three common oral hypoglycemic medications.
  • In 2011, Life Extension reports that new research confirms blueberry polyphenols, previously reported to support cognitive health, also target factors that contribute to metabolic syndrome, including high blood sugar, high blood pressure, insulin resistance, and adverse lipid blood profiles.
  • In 2011, Life Extension reports a landmark aging-reversal study published in the November 28, 2010, online edition of the scientific journal Nature which showed that prematurely aged mice whose telomeres were lengthened experienced a rapid reversal of degenerative pathologies. In response to this unprecedented finding, Life Extension funds $2 million for a new aging-reversal study that will include telomere lengthening.

  • In 2011, Life Extension introduces a proprietary complex of bioactive milk peptides, widely used in Europe to promote sustained and restful sleep patterns and promote a healthy response to stress.

  • In 2011, Life Extension introduces fucoidans, the long-chain molecules found primarily in edible seaweeds native to the Japanese diet. In nearly 900 different studies, fucoidans are shown to promote healthy immune function, cell-to-cell communication, and tissue repair. Many experts believe that fucoidans are one of the key nutrients responsible for the long healthy lives of people in Okinawa, which for decades boasted the world’s highest concentration of centenarians.

  • In 2011, Life Extension exposed how the FDA's failure to allow widespread use of low-dose aspirin resulted in three million needless cancer deaths in the United States. In an eye-opening report published by Oxford University in The Lancet in 2010, long-term low-dose aspirin therapy (75 mg per day) reduced the overall risk of cancer death by 20%. These findings demonstrate that low-dose aspirin therapy could have saved millions from cancer and vascular diseases since Life Extension first recommended daily aspirin use in 1983.

  • In 2011, Life Extension published a book (Pharmocracy) that exposed how inefficient and corrupt government practices stifle medical innovation and cause healthcare prices to spiral out of control. Pharmocracy advocates the repeal of draconian laws that have granted a virtual monopoly to the entrenched medical establishment and warns the nation's solvency is at stake unless free market reforms are implemented.

  • In 2011, Life Extension identified more therapies being irrationally suppressed by the FDA that could save the lives of cancer victims.

  • In 2011, Life Extension revealed the lethal dangers of even one omission. In this instance, it appears that legendary health guru Jack LaLanne died too early from a disorder that could have been prevented.

  • In 2011, Life Extension introduced a novel green coffee extract shown to induce weight loss by inhibiting absorption of calories from starches and sugars while lowering lipids and inhibiting after-meal blood glucose spikes.

  • In 2011, at the French-American BioTech Symposium, Dr. Michael West presented data on the restoration of cell life span using transcriptional reprogramming technology. This was funded in part with funds contributed by the Life Extension Foundation.

  • In 2012, in an effort to combat the increasing incidence of Nonalcoholic Fatty Liver Disease, Life Extension introduced a phyto-supplement containing extracts from the adaptogenic vine Schisandra chinensis and from muskmelon. This formulation helps to detoxify the liver and restore its antioxidant function to youthful levels.

  • In 2012, to help support healthy blood pressure, Life Extension formulated a product featuring oleuropein, a compound found in high concentration in the olive leaf, which has been shown to favorably modulate arterial resistance or stiffness.

  • In 2012, Life Extension published findings on a non-toxic experimental treatment it funded that resulted in 80% survival of women with stage IV breast cancer.

  • In 2013, Life Extension introduced the first enzyme formulation that facilitates digestion of dietary protein, fiber, and fat — without promoting the breakdown of starches and the rapid absorption of glucose into the bloodstream that triggers postprandial glucose surges.

  • In 2013, Life Extension researchers analyzed 12 independent studies that evaluated blood glucose levels and breast cancer risk and found that 9 of the studies revealed a correlation between higher fasting glucose, or other indicators of poor glycemic control, and increased risk of cancer.

  • In 2013, to enhance the body’s absorption of astaxanthin, Life Extension formulated this antioxidant carotenoid with phospholipids, clinically shown to boost astaxanthin absorption several-fold.

  • In 2013, Life Extension introduced a formula utilizing the digestive enzyme transglucosidase, which is scientifically shown to transform starches into prebiotic fiber in the digestive tract, helping to support healthy glucose and insulin levels.

Membership in the non-profit Life Extension Foundation® is at an all-time high. Life Extension is growing because people are becoming aware that recommendations published by the Foundation in the early 1980s are now scientifically validated, and many are even accepted by the medical establishment.

The Life Extension Foundation® disseminates this practical life-saving information each month to its members in Life Extension Magazine®. Membership normally costs $75 a year, but members save far more than this on blood tests, compounded prescription drugs, state-of-the-art nutritional supplements, and free telephone access to knowledgeable Health Advisors.

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