Life Extension Magazine November 2003
As We See It
|Startling New Findings About Homocysteine|
Dramatic Reduction in Blood Testing Prices
The retail price of a homocysteine blood test at a commercial laboratory is over $180. Life Extension members used to pay $85 for it. Under the new lower pricing structure, members of The Life Extension Foundation can obtain a homocysteine blood test for only $64.
We are pleased to announce these price reductions because we know that blood tests provide a solid scientific basis for keeping Foundation members alive longer. I cannot tell you how many early-stage prostate cancers have been diagnosed because of the convenient mail-order blood-testing service we offer.
I urge all Foundation members to have their blood tested at least once a year. If homocysteine levels are elevated, aggressive actions should be undertaken to lower it. After higher amounts of nutrients such as TMG and vitamin B6 have been taken for 30-90 days, another homocysteine blood test should be done to make sure levels are below 7-8 (µmol/L).
While people often fear cancer more than cardiovascular disease, the irrefutable fact is that heart attack and stroke kill far more Americans than cancer and most other diseases combined. Overwhelming evidence suggests that keeping blood markers such as homocysteine in safe ranges can dramatically reduce the risk of vascular disease.
I personally have been a beneficiary of having my blood tested and always recommend it on my media appearances. View information on the most important annual blood test for men and women to consider.
For longer life,
1. Salles-Montaudon N, Parrot F, Balas D, Bouzigon E, Rainfray M, Emeriau JP. Prevalence and mechanisms of hyperhomocysteinemia in elderly hospitalized patients. J Nutr Health Aging. 2003;7(2):111-6.
2. Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995 Nov 15;92(10):2825-30.
3. Ventura P, Panini R, Verlato C, Scarpetta G, Salvioli G. Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects. Metabolism. 2001 Dec;50(12):1466-71.
4. Naurath HJ. Hyperhomocysteinemia in advanced age. Clin Chem Lab Med. 2001 Aug;39(8):695-7.
5. Wilcken DE, Reddy SG, Gupta VJ. Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria. Metabolism. 1983 Apr;32(4):363-70.
6. Mudd SH, Havlik R, Levy HL, McKusick VA, Feinleib M.A study of cardiovascular risk in heterozygotes for homocystinuria. Am J Hum Genet. 1981 Nov;33(6):883-93.
7. Rossouw JE, Labadarios D, Jooste PL, Shephard GS. Lack of a relationship between plasma pyridoxal phosphate levels and ischaemic heart disease. S Afr Med J. 1985 Apr 6;67(14):539-41.
8. Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, et al. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med. 1998 Apr 9;338(15):1009-15.
9. Tucker KL, Mahnken B, Wilson PW, Jacques P, Selhub J. Folic acid fortification of the food supply. Potential benefits and risks for the elderly population. JAMA. 1996 Dec 18;276(23):1879-85.
10. Verhoef P, Stampfer MJ, Buring JE, Gaziano JM, Allen RH, Stabler SP, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol. 1996 May 1;143(9):845-59.
11. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992 Aug 19;268(7):877-81.
12. references no longer posted
13. references no longer posted
14. references no longer posted
15. Zeng X, Dai J, Remick DG, Wang X. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res. 2003 Aug 22;93(4):311-20.
16. Elian KM, Hoffer LJ. Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease. Metabolism. 2002 Jul;51(7):881-6.
17. Bostom AG, Shemin D, Lapane KL, Hume AL, Yoburn D, Nadeau MR, et al. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int. 1996 Jan;49(1):147-52.