By a News Reporter-Staff News Editor at Drug Week -- A new study on Peptides is now available. According to news reporting originating from Tehran, Iran, by NewsRx correspondents, research stated, "Several strategies have been proposed for the prevention of vancomycin-induced nephrotoxicity. Here, we review available evidence supporting the respective strategies."
Our news editors obtained a quote from the research from the University of Tehran, "Data were collected by searching the Scopus, PubMed, and Medline databases and the Cochrane database of systematic reviews. The key words used as search terms were 'vancomycin,' 'nephrotoxicity', 'renal failure,' 'renal damage,' 'nephroprotective,' 'renoprotective', and 'prevention.' Prospective or retrospective observational animal studies that evaluated the effects of a modality for the prevention of vancomycin-induced nephrotoxicity was included. Animal studies show beneficial effects of various antioxidants, such as erdosteine, vitamin E, vitamin C, N-acetylcysteine, caffeic acid phenethyl ester, and erythropoietin, in the prevention of vancomycin-induced nephrotoxicity."
According to the news editors, the research concluded: "However, before these agents can be used in clinical practice, their potential benefits must be confirmed in future randomized controlled human studies."
For more information on this research see: Prevention of vancomycin induced nephrotoxicity: a review of preclinical data. European Journal of Clinical Pharmacology, 2013;69(4):747-754. European Journal of Clinical Pharmacology can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; European Journal of Clinical Pharmacology - www.springerlink.com/content/0031-6970/)
The news editors report that additional information may be obtained by contacting S. Elyasi, Univ Tehran Med Sci, Fac Pharm, Dept. of Clin Pharm, Tehran 1417614411, Iran (see also Peptides).
Keywords for this news article include: Iran, Asia, Tehran, Vancomycin, Glycopeptides
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