By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies have been published. According to news reporting out of Ahwaz, Iran, by NewsRx editors, research stated, "Free radical induced neural damage is implicated in cerebral hypoperfusion disorders and antioxidants have protective effects. In the present study, we examined the effect of gallic acid (GA; 100 mg/kg, p.o. for 10 days) on cognitive deficit and cerebral oxidative stress induced by permanent bilateral common carotid artery occlusion (2VO) as an animal model of vascular dementia (VD)."
Our news journalists obtained a quote from the research from Ahvaz Jundishapur University, "The results showed that 2VO significantly reduced the spatial memory performance in Morris water maze as well as non enzymatic (total thiol) and enzymatic [glutathione peroxidase (GPx)] antioxidant contents and increased the level of malondialclehyde (MDA) in the hippocampus and frontal cortex of vehicle-treated group as compared to sham-operated rats. Furthermore, chronic administration of GA significantly restored the spatial memory, total thiol and GPx contents and also decreased MDA levels in these tissues. GA alone did not show any change neither in the status of various antioxidants nor behavioral tests over sham values. The results demonstrate that GA has beneficial activity against 2VO-induced cognitive deficits via enhancement of cerebral antioxidant defense."
According to the news editors, the research concluded: "Taken together, the present study suggested that GA might be useful in the treatment of VD."
For more information on this research see: Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats. European Journal of Pharmacology, 2014;733():62-67. European Journal of Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmacology - www.elsevier.com/wps/product/cws_home/506087)
Our news journalists report that additional information may be obtained by contacting M.S. Korani, Ahvaz Jundishapur Univ Med Sci, Sch Med, Atherosclerosis Res Center, Ahwaz, Iran. Additional authors for this research include Y. Farbood, A. Sarkaki, H.F. Moghaddam and M.T. Mansouri (see also Drugs and Therapies).
Keywords for this news article include: Iran, Asia, Ahwaz, Drugs and Therapies
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