Balochistan Times (Pakistan)
Just as exposure to carcinogens increases a person’s risk for cancer, experts now believe in a new research that class of environmental toxins -known as gerontogens - may put people at an increased risk for accelerated aging.
Toxins present in cigarette smoke, UV rays and chemotherapy are all suspected gerontogens - capable of accelerating the rate at which a person ages,
In a new study published in Trends in
Aging occurs when the body undergoes a biological process known as senescence, when healthy cells become damaged and lose their ability to divide.
Over time, these damaged cells accumulate in the body, consuming resources and unleashing hormones with inflammatory properties.
“Having a few [of these cells] is not a big deal,” Sharpless said. “But over the course of a lifetime, as they accumulate, they [contribute to] aging and many of the diseases we associate with aging.”
In their study, Sharpless and his colleagues developed a system that allowed them to expose mice to certain gerontogens and then measure the accumulation of senescence cells in their bodies. Each group of mice was exposed to a different environmental factor: Some were made obese, while others were exposed to cigarette smoke, UV light and arsenic.
According to their results, both cigarette smoke and UV light were strongly associated with accelerated aging, while obesity and arsenic exposure did not appear to have a significant impact on senescence.
“Our work reasonably says cigarette smoking is the thing we could really do something about that would benefit the aging biology of a large number of people,” Sharpless said. “But we’re also reasonably certain there are other gerontogens we don’t know about yet.”
The researchers hope that other labs will use their experimental models to test how other toxins might impact the aging process.
“Chemo for breast cancer increases molecular age by about 15 years equivalent of chronologic aging; that’s a lot,” Sharpless said. “But it’s not surprising to oncologists. We’ve known for a long time there is long-term toxicity with these drugs.”
Sharpless and his colleagues hope that tests offering a better measure of a person’s “physiologic” age might help doctors develop more appropriate treatment methods for different kinds of patients.
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