Back in 1999, a drug called orlistat was approved by the FDA to facilitate weight loss. Orlistat works by inhibiting the lipase enzyme in the digestive tract. When taken before a meal, orlistat will prevent about 30% of ingested fat from being absorbed into the bloodstream. Since fat grams contain twice as many calories as protein or carbohydrate, orlistat targets a significant offender involved in the accumulation of excess body weight.
Some studies show impressive weight-loss results when 120 mg of orlistat is taken before each meal (three times a day). One study showed that overweight women who followed a lifestyle modification program and took orlistat lost 20.5 pounds after one year compared with virtually no weight loss in the control group.1 In a study of obese men taking orlistat, 17.4 pounds of weight was lost after three months.2 Not all studies yield these favorable results.
Life Extension® believes the reason that orlistat fails many consumers is that it inhibits only one of many factors involved in today’s obesity epidemic. Life Extension also believes that while orlistat blocks the absorption of 30% of dietary fat, the 70% of ingested fat that is absorbed can preclude significant weight loss. Compared with a reduced calorie diet alone, those who take orlistat can expect to lose 50% more weight.3 That means if you are able to lose 20 pounds through diet alone, taking orlistat would improve the amount of weight lost to 30 pounds.
Why you should try Orlistat for 60-90 days
Those embarking on a weight-loss program expect to see relatively rapid results. While orlistat has yielded only modest effects by itself, its unique mechanism of blocking 30% of dietary fat from being absorbed provides an important weapon in a comprehensive fat-loss armamentarium.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
1. Eat Weight Disord. 2006 Mar;11(1):e35-41.
2. Metab Syndr Relat Disord. 2005 Summer;3(2):122-9.
3. Data on file, GlaxoSmithKline Consumer Healthcare.
alli® is a registered trademark of GlaxoSmithKline.
|Dosage and Use|
For overweight adults 18 years and older: